Collagen Type XI Alpha 1 (COL11A1): A Novel Biomarker and a Key Player in Cancer

Analyzing Collagen Alpha 1(XI) Using a Zebrafish Model System

Zebrafish (Danio rerio) are progressively becoming more popular as a model organism for research. The use of zebrafish is advantageous for several reasons. Zebrafish are small in size, exhibit high fecundity, rapidly generate, are transparent during development and are easily maintained in large numbers. Using zebrafish as a model organism, the aim of this project is to determine the function o...

Differential expression of collagen type V and XI alpha-1 in human ascending thoracic aortic aneurysms.

BACKGROUND The molecular mechanisms leading to ascending thoracic aortic aneurysms (ATAAs) remain unknown. We hypothesized that alterations in expression levels of specific fibrillar collagens occur during the aneurysmal process. METHODS Surgical samples from ascending aortas from patients with degenerative ATAAs were subdivided by aneurysm diameter: small, 5 to 6 cm; medium, 6 to 7 cm; and l...

Collagen Type XI Alpha 1 Expression in Intraductal Papillomas Predicts Malignant Recurrence

Despite the progress achieved in the treatment of breast cancer, there are still many unsolved clinical issues, being the diagnosis, prognosis, and treatment of papillary diseases, one of the highest challenges. Because of its unpredictable clinical behavior, treatment of intraductal papilloma has generated a great controversy. Even though considered as a benign lesion, it presents high rate of...

COL 1 A 1 ( collagen , type I , alpha 1 )

Alpha 1-antitrypsin. A novel biomarker for obesity in humans.

OBJECTIVE To investigate the relationship between alpha 1-antitrypsin (A1AT), adiponectin, leptin, blood glucose, and insulin protein levels in human serum and obesity. METHODS Forty-eight subjects with normal blood glucose levels and average age of 32.4+/-5.1 years were enrolled in this study. The study took place in the Reproductive Center, The Second Hospital of Jilin University, Changchun...